NanoKnife® Therapy

The NanoKnife Therapy based on Irreversible electroporation (IRE) – a breakthrough in prostate cancer therapy.


Treating prostate cancer – no pain, impotence or incontinence; a one-time, one-day (24 hours) treatment, no rehab or aftercare necessary, no scars or radiation damage, no hindrance to follow-up therapy.

Until just recently, this was unthinkable. Now, it’s reality.

The Prostate Center have become the world’s leaders in developing the irreversible electroporation (IRE, NanoKnife®) method and it is ready for use to treat prostate cancer.

Unlike all other treatment procedures, NanoKnife® only destroys cells; vital tissue structures are not affected. This makes NanoKnife (IRE) the first tissue-selective form of therapy and the beginning of a new generation of therapy.

For more information:

Prostate Cancer Therapies

What is the “best” Prostate Cancer treatment?

prostatakrebs Radical surgical removal (prostatectomy)?     DaVinci?   Nerve-sparing operation?   Radiation therapy?   Proton therapy?    CyberKnife®?   LDR Brachy therapy (seeds)?    HIFU?   Laser thermotherapy?   RFA?   NanoKnife® (irreversible electroporation)?   Immunotherapies?    Cryotherapy?    Photodynamic therapy (PDT)?    Hormone therapy?    Active surveillance?    Watchful waiting? ….

Have you only been told about two options: an operation and/or radiation therapy? That is not the full picture. There are many treatment options for prostate cancer – and new ones are being developed in an ever shorter intervals. This makes it difficult not only for patients, but even for many doctors, to stay up to date and well informed.
At the Prostate Center, we advise you thoroughly and independently about all of the treatment options for prostate cancer so that you can find the treatment that is best for you.
We at the Prostate Center are the world’s leaders in NanoKnife® treatment of prostate cancer with irreversible electroporation – the latest advancement cellular level treatment without pain, impotence or incontinence.

You can trust our international team of urologists, radiologists, radiotherapists, internists, anesthesiologists and physicists when it comes to a decision that can change your life.
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Transperineal 3-d mapping biopsy

MRI-guided 3-d mapping biopsy with Histo-Modelling®:MRI-guided 3-d mapping biopsy with Histo-Modelling®: a necessary step for the new generation of focal therapy.

At the Prostate Center, we have drawn the logical conclusion from the drawbacks of rectal punch biopsy and developed a new biopsy method. The 3-d biopsy is more than three times as accurate as standard biopsies, is three-dimensional, MRI-guided, precise, painless under general anesthesia and without risk of infection. It overcomes all of the drawbacks of rectal punch biopsies and, in conjunction with MRI, is becoming an essential tool for every type of focal therapy (therapy targeted at cancer locations or “foci”). At the Prostate Center, we have further developed this type of biopsy especially for NanoKnife® treatment. Using “Histo-Modelling®”, we are able to use biopsy data to create an interactive 3-d model of the prostate that shows the distribution of all cancer foci and how dangerous each is (Gleason score). This development makes it possible for the first time to control focal therapy precisely by using all of this information, and makes us the current worldwide leaders.

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Michael K. Stehling, MD, PhD

Michael K. Stehling, MD, PhD – Professor of Radiology, Lecturer at LMU Munich, fmr. Associate Professor of Radiology at Boston University, USA.
Prof. Stehling served as Research Assistant to Sir Peter Mansfield, Prof of Physics and Nobel Prize winner in Medicine in 2003 (for discoveries concerning magnetic resonance imaging). The Prostate-Center was founded in 2010 by Prof. Michael K. Stehling. At the Prostate-Center physicians, scientists and engineers collaborate closely to offer state of the art diagnostics and the most promising and innovative minimally invasive treatment technologies.

Stefan Zapf, MA, MD

Dr Zapf

Stefan Zapf, MA, MD, studied Biology and Medicine at the University of Mainz, Germany. Specializing in diagnostic and interventional radiology he was in leading position in radiation therapy and radiology at university hospital in Mainz. Specializing on novel minimally invasive therapies, he has been managing the interventional radiology unit at the Institut fuer Bildgebende Diagnostik and Prostate Center since 2005. Together with Prof. Stehling he is leading in the field of Pulsed Electric Field therapies with most interventions of inner organs worldwide.

Prostate Center Germany


Strahlenberger Straße 110

63067 Offenbach am Main